No molecule is ever alone, so Suzette wants to understand how different types RNA folds in the presence of binding partners, like small and big proteins, inside and outside complex molecular machines and when surrounded by different types of counterions and ligands. Outside the lab, Suzette loves spending time with her family in their backyard; when bored with that she practices top rope rock climbing or running from zombies (using the Zombies Run app).
Yen’s research focuses are the following: 1. Studying RNA conformations in vitro using single-molecule techniques and small-angle x-ray scattering (SAXS) 2. High-throughput forward modeling of solution x-ray scattering profiles, with explicit ions and solvent molecules 3. Wide-angle x-ray scattering 4. Statistical and molecular modeling of experimental observables
Outside of the lab, Yen plays competitive volleyball and he has won championships in more than 10 intramural leagues from indoor to sand volleyball.
Alex works on analyzing the structural dynamics of nucleosomes using novel computational modeling methods. When he isn’t purifying proteins or coding in the lab, he enjoys going on hikes with his dog and playing board games with friends.
Derrick works on discovering the structure of RNA through techniques like electron microscopy and computational analysis. Outside of the lab, he enjoys playing video games and arranging music—and, naturally, arranging video game music.
In the lab, Alex develops experimental tools and technologies to address challenging problems in RNA directed therapeutics. His main focus is on providing microfluidic platforms to allow high-throughput screening of small molecule inhibitors to functional RNA elements, such as riboswitches. Outside of the lab, Alex can be found trail running around Ithaca, running in both freezing Winter rain and scorching Summer sun and regularly participates in the annual Ithaca half marathon. In addition to these outdoor pursuits, Alex enjoys playing electric guitar in genres ranging from country to progressive metal.
Before imaging protein-RNA complexes, it is vital that laboratories know with certainty that proper association has formed the desired complexes. Luke studies agarose gel and how it can be best utilized to verify the existence of these creations in a sample. When not at his desk, you are likely to find Luke on top of a mountain with a snowboard strapped to his legs or working on music production.